Publications

1. L. Böttcher, S. Felder, Optimal sequencing of multiple tests, medRxiv:2025.03.12.25323851
2. Y. Ge, L. Böttcher, T. Chou, M. R. D'Orsogna, Efficient portfolio selection through preference aggregation with quicksort and the Bradley--Terry model, preprint
3. T. Wong, L. Böttcher, T. Chou, M. R. D'Orsogna, Sharp rises in alcohol-induced deaths in the United States (1999-2022) across genders, ages, races, medRxiv:2024.12.10.24318758
4. L. Böttcher, M. A. Porter, Clustering-induced localization of quantum walks on networks, arXiv:2412.04325
5. Y. Ge, L. Böttcher, T. Chou, M. R. D'Orsogna, A knapsack for collective decision-making, arXiv:2409.13236
6. J. Zhang, X. Li, X. Guo, Z. You, L. Böttcher, A. Mogilner, T. Chou, A. Hoffmann, M. Xia, Reconstructing noisy gene regulation dynamics using extrinsic-noise-driven neural stochastic differential equations, arXiv:2503.09007
7. N. Owusu-Boaitey, L. Böttcher, D. He, R. Erkhembayar, L. Yang, D.-H. Kim, A. Barchuk, D. H. Gorski, J. Howard, Impact of cross-reactivity and herd immunity on SARS-CoV-2 pandemic severity, Infect. Dis. (2024)
8. J. Li, T. Asikis, I. Fragkos, L. Böttcher, idinn: Inventory-dynamics control with neural networks, GitLab repo
9. L. Böttcher, M. R. D'Orsogna, T. Chou, Aggregating multiple test results to improve medical decision-making, PLOS Comput. Biol. 21, e1012749 (2025), arXiv:2409.16442, GitLab repo
10. L. Böttcher, L. L. Fonseca, R. C. Laubenbacher, Control of medical digital twins with artificial neural networks, Phil. Trans. R. Soc. A 383, 20240228 (2025), arXiv:2403.13851, biorxiv:2024.03.18.585589, GitLab repo
11. L. Böttcher, M. A. Porter, Dynamical processes on metric networks, SIAM J. Appl. Dyn. Syst. (2025), arXiv:2401.00735, GitLab repo
12. L. L. Fonseca, L. Böttcher, B. Mehrad, R. C. Laubenbacher, Optimal control of agent-based models via surrogate modeling, PLOS Comput. Biol. 21, e1012138 (2025), arXiv:2402.05750, GitHub repo
13. L. Böttcher, T. Chou, M. R. D'Orsogna, Forecasting drug overdose mortality by age in the United States at the national and county levels, PNAS Nexus 3, pgae050 (2024), GitLab repo, arXiv:2309.14452, medRxiv:2023.09.25.23296097
14. H. Masoomy, T. Chou, L. Böttcher, Impact of random and targeted disruptions on information diffusion during outbreaks, Chaos 33, 033145 (2023), arXiv:2301.00748, GitLab repo
15. L. Böttcher, M. A. Porter, Complex networks with complex weights, Phys. Rev. E 109, 024314 (2024), arXiv:2212.06257, GitLab repo
16. L. Böttcher, J. J. F. Breedvelt, F. C. Warren, Z. Segal, W. Kuyken, C. L. H. Bockting, Identifying relapse predictors in individual participant data with decision trees, BMC Psychiatry 23, 835 (2023), PsyArXiv:69ezt
17. L. Böttcher, G. Wheeler, Visualizing high-dimensional loss landscapes with Hessian directions, J. Stat. Mech. Theory Exp., 023401 (2024), arXiv:2208.13219, GitLab repo
18. L. Böttcher, T. Chou, M. R. D'Orsogna, Modeling and forecasting age-specific overdose mortality in the United States, Eur. Phys. J. Spec. Top. 232, 1743--1752 (2023), GitLab repo, arXiv:2303.16172
19. L. Böttcher, R. Klingebiel, Organizational selection of innovation, Organ. Sci. 36, 387--410 (2025), arXiv:2405.09843, Gitlab repo
20. L. Böttcher, T. Asikis, Near-optimal control of dynamical systems with neural ordinary differential equations, Mach. Learn.: Sci. Technol. 3, 045004 (2022), arXiv:2206.11120, Gitlab repo
21. D. Wernli, L. Böttcher, F. Vanackere, Y. Kaspiarovich, M. Massood, N. Levrat, Understanding and governing systemic crises in the 21st century: a review from a complexity perspective, Glob. Policy 14, 207--228 (2023)
22. L. Böttcher, S. Wald, T. Chou, Mathematical characterization of private and public immune repertoire sequences, Bull. Math. Biol. 85, 102 (2023), arXiv:2205.08750, biorxiv:2022.05.17.492232, Gitlab repo
23. M. R. D'Orsogna, L. Böttcher, T. Chou, Fentanyl-driven acceleration of racial, gender and geographical disparities in drug overdose deaths in the United States, PLOS Glob. Public Health 3, e0000769 (2023), medRxiv:2022.06.22.22276766
24. M. Xia, L. Böttcher, T. Chou, Spectrally adapted physics-informed neural networks for solving unbounded domain problems, Mach. Learn.: Sci. Technol. 4, 025024 (2023), arXiv:2202.02710, Gitlab repo
25. L. Böttcher, T. Asikis, I. Fragkos, Control of dual-sourcing inventory systems using recurrent neural networks, INFORMS J. Comput. 35, 1308--1328 (2023), arXiv:2201.06126, IJoC GitHub repo
26. N. Antulov-Fantulin, L. Böttcher, On the accuracy of short-term COVID-19 fatality forecasts, BMC Infect. Dis. 22, 251 (2022), arXiv:2107.09891, GitHub repo
27. L. Böttcher, H. Gersbach, D. Wernli, Restoring the antibiotic R&D market to combat the resistance crisis, Sci. Public Policy 49, 127--131 (2022)
28. M. Xia, L. Böttcher, T. Chou, Controlling epidemics through optimal allocation of test kits and vaccine doses across networks, IEEE Trans. Netw. Sci. Eng. 9, 1422--1436 (2022), arXiv:2107.13709, GitLab repo
29. T. Schneider, O. R. A. Dunbar, J. Wu, L. Böttcher, D. Burov, A. Garbuno-Inigo, G. L. Wagner, S. Pei, C. Daraio, R. Ferrari, J. Shaman, Epidemic management and control through individual risk-tailored contact interventions, PLOS Comput. Biol. 18, e1010171 (2022), arXiv:2109.10970, GitHub repo
30. L. Böttcher, N. Antulov-Fantulin, T. Asikis, AI Pontryagin or how artificial neural networks learn to control dynamical systems, Nat. Commun. 13, 333 (2022), arXiv:2103.06525, GitHub repo
31. L. Böttcher, M. R. D'Orsogna, T. Chou, A statistical model of COVID-19 testing in populations: effects of sampling bias and testing errors, Phil. Trans. R. Soc. A 380, 20210121 (2021), medRxiv:2021.05.22.21257643, arXiv:2105.11961, GitHub repo
32. L. Böttcher, J. Nagler, Decisive conditions for strategic vaccination against SARS-CoV-2, Chaos 31, 101105 (2021), medRxiv:2021.03.05.21252962, GitHub repo
33. L. Böttcher, G. Kernell, Examining the limits of the Condorcet Jury Theorem: Tradeoffs in hierarchical information aggregation systems, Collect. Intell. 1, 1--16 (2022), arXiv:2110.02298
34. D. Wernli, M. Clausin, N. Antulov-Fantulin, J. Berezowski, N. Biller, K. Blanchet, L. Böttcher, C. Burton-Jeangros, G. Escher, A. Flahault, K. Fukuda, D. Helbing, P. D. Jaffé, P. S. Jørgensen, Y. Kaspiarovich, J. Krishnakumar, J. Berezowski, R. J. Lawrence, K. Lee, A. Léger, N. Levrat, R. Martischang, C. M. Morel, D. Pittet, M. Stauffer, F. Tediosi, F. Vanackere, J.-D. Vassalli, G. Wolff, O. Young, Building a multisystemic understanding of societal resilience to the COVID-19 pandemic, BMJ Glob. Health 6, e006794 (2021)
35. L. Böttcher, M. R. D'Orsogna, T. Chou, Using excess deaths and testing statistics to determine estimates of COVID-19 mortalities, Eur. J. Epidemiol. 36, 545--558 (2021), medRxiv:2021.01.10.21249524, arXiv:2101.03467, GitHub repo
36. L. Böttcher, M. A. Porter, Classical and quantum random-walk centrality measures in multilayer networks, SIAM J. Appl. Math. 81, 2704--2724 (2021), arXiv:2012.07157, Gitlab repo
37. S. Wald, L. Böttcher, From classical to quantum walks with stochastic resetting on networks, Phys. Rev. E 103, 012122 (2021), arXiv:2008.00510, GitHub repo
38. T. Asikis, L. Böttcher, N. Antulov-Fantulin, Neural ordinary differential equation control of dynamics on graphs, Phys. Rev. Res. 4, 013221 (2022), arXiv:2006.09773, GitHub repo
39. P. Richter, M. Henkel, L. Böttcher, Aging and equilibration in bistable contagion dynamics, Phys. Rev. E 102, 042308 (2020), arXiv:2006.05937
40. S.D.S. Reis, L. Böttcher, J.P. da C. Nogueira, G.S. Sousa, A.S. Lima Neto, H.J. Herrmann, J.S. Andrade Jr, Spatio-temporal characteristics of dengue outbreaks, Front. Phys. 10, 923099 (2022), arXiv:2006.02646
41. L. Böttcher, M. Xia, T. Chou, Why case fatality ratios can be misleading: individual- and population-based mortality estimates and factors influencing them, Phys. Biol. 17, 065003 (2020), arXiv:2003.12032, medRxiv:2020.03.26.20044693
42. L. Böttcher, N. Antulov-Fantulin, Unifying continuous, discrete, and susceptible-infected-recovered processes on networks, Phys. Rev. Res. 2, 033121 (2020), arXiv:2002.11765
43. L. Böttcher, H. Gersbach, A refunding scheme to incentivize narrow-spectrum antibiotic development, Bull. Math. Biol. 84, 59 (2022), arXiv:2007.06468, medRxiv:2020.07.13.20152652, CEPR:DP15512
44. F. D'Angelo, L. Böttcher, Learning the Ising model with generative neural networks, Phys. Rev. Res. 2, 023266 (2020), arXiv:2001.05361, GitHub repo
45. L. Böttcher, A random-line-graph approach to overlapping line segments, J. Complex Netw. 8, cnaa029 (2020), arXiv:1911.10679
46. S. Nauer, L. Böttcher, M. A. Porter, Random-graph models and characterization of granular networks, J. Complex Netw. 8, cnz037 (2019), arXiv:1907.13424
47. S. Xu, L. Böttcher, T. Chou, Diversity in biology: definitions, quantification, and models, Phys. Biol. 17, 031001 (2020), arXiv:1908.08190
48. L. Böttcher, H. Gersbach, The great divide: Quantifying drivers of polarization in the US public, EPJ Data Sci. 9, 32 (2020), arXiv:2001.05163, GitLab repo
49. L. Böttcher, P. Montealegre, E. Goles, H. Gersbach, Competing activists--political polarization, Physica A 545, 123713 (2019), arXiv:1910.14531
50. S. Strub, L. Böttcher, Modeling deformed transmission lines for continuous strain sensing applications, Meas. Sci. Technol. 31, 035109 (2019), arXiv:1912.13319
51. M. Hoferer, L. Böttcher, H.J. Herrmann, H. Gersbach, The impact of technologies in political campaigns, Physica A 538, 122795 (2019), arXiv:1909.07644
52. L. Böttcher, H.J. Herrmann, H. Gersbach, Clout, activists and budget: The road to presidency, PLOS One 13(3):e0193199. (2018), arXiv:1802.02048
53. L. Böttcher, H.J. Herrmann, M. Henkel, Dynamical universality of the contact process, J. Phys. A 51, 125003 (2018), arXiv:1802.00037
54. L. Böttcher, J. S. Andrade Jr., H.J. Herrmann, Targeted recovery as an effective strategy against epidemic spreading, Sci. Rep. 7, 14356 (2017), arXiv:1710.05807
55. L. Böttcher, J. Nagler, H.J. Herrmann, Critical behaviors in contagion dynamics, Phys. Rev. Lett. 118, 088301 (2017), arXiv:1701.08988, GitHub repo
56. L. Böttcher, O. Woolley-Meza, D. Brockmann, Temporal dynamics of online petitions, PLOS One 12(5):e0178062. (2017), arXiv:1705.04202
57. L. Böttcher, M. Lukovic, J. Nagler, S. Havlin, H.J. Herrmann, Failure and recovery in dynamical networks, Sci. Rep. 7, 41729 (2017), arXiv:1610.00997
58. L. Böttcher, O. Woolley-Meza, E. Goles, D. Helbing, H.J. Herrmann, Connectivity disruption sparks explosive epidemic spreading, Phys. Rev. E 93, 042315 (2016), arXiv:1604.07783
59. L. Böttcher, N.A.M. Araújo, J. Nagler, J.F.F. Mendes, D. Helbing, H.J. Herrmann, Gender gap in the ERASMUS mobility program, PLOS One 11(2):e0149514. (2016), arXiv:1602.01442
60. L. Böttcher, O. Woolley-Meza, N.A.M. Araújo, H.J. Herrmann, D. Helbing, Disease-induced resource constraints can trigger explosive epidemics, Sci. Rep. 5, 16571 (2015), arXiv:1508.05484, ssrn.2496128
61. R. Mani, L. Böttcher, H.J. Herrmann, D. Helbing, Extreme power law in a driven many-particle system without threshold dynamics, Phys. Rev. E 90, 042201 (2014), arXiv:1404.7460